Background: UTI is the most common nosocomial and community acquired infection in underdeveloped and developing countries around the world. The incidence is also increasing day by day which may lead to in bacteremia and renal failure. ‘Women are more susceptible to UTIL. Though the findings of urinary pathogens do not change much in different settings but resistance to anti-microbial drugs are increasing due to indiscriminate and irrational use. So, in this present study the prevalence of UTI in patients of this hospital was investigated. As well as clinical profile of those patients and their drug resistance pattern has been studied. Materials & Methods : This was a prospective cross sectional trial conducted in TMC & RCH on 250 suspected cases of UTI from October 2016 to march 2017. Data was collected from inpatient and outpatient department of medicine using questionnaire form. Sample was collected at early morning for Urine R/M/E, Urine Culture and Sensitivity investigation. Urine was collected from each patient into a 20mL calibrated sterile screw-capped universal container supplied to the patients. The specimens were labeled, transported to the laboratory, and analyzed within 6 hours. All patients were well instructed on how to collect sample aseptically prior to sample collection to avoid contaminations from urethra. Verbal & written informed consent was obtained from all patients prior to specimen collection. Results : Among 250 patients 60.4% were females, 58.4% patients were illiterate and 68% were from low socio-economic condition. 63.6% patients had symptoms of UTI for<6 weeks and 26.4 % samples revealed positive from urinary culture. Among the uro pathogens E.coli is the most frequently found bacteria (57.58%) and most of the patients are susceptible to parenteral drugs like amikacin, gentamicin and meropenem. There is also moderate resistance against nitrofurantoin. Conclusion : In this study, 58.4% of the patients were illiterate and 68% patients were from low- socioeconomic condition. Moreover, most of the patients were resistant to frequently used oral antimicrobial drugs and susceptibility remains toward injectable anti- microbial drugs increasing the economic burden as well as the morbidity of the patients. So, adequate health education should be given to people of low socio economic condition about maintaining personal hygiene. Physicians should also prescribe antimicrobial drugs according to culture and sensitivity report as much as possible. And local antibiogram should be followed for empirical therapy.

Urinary tract infection, Frequency, Clinical profile, Antimicrobial profile

Urinary Tract Infection (UTI) has become the most common hospital-acquired infection, accounting for as many as 35 % of nosocomial infections, and it is the second most common cause of bacteraemia in hospitalized patients.! On the other hand, women are more susceptible to UTI in the community . About 20% of women experience a single episode of UTI during their lifetime, and 3% of women have more than one episode of UTI per year’. Pregnancy also makes them more susceptible to infection’. With advancing age, the incidence of UTI increases in men due to prostate enlargement and neurogenic bladder.* Also 5% patients in the hospital develop catheter associated UTL® This could lead to irreversible renal damage resulting in renal failure also.® This also increases the economic burden of the patients. UTI caused by a range of pathogens, but most Predominantly Escherichia coli, Staphylococcus aureus, enterococcus spp., pseudomonus spp., Proteus spp., providencia spp., acentobacter spp., klebsiella spp., citrobacter spp., Neisseria gonorrhoeae and other pathogens.” In almost all cases, there is a need to start treatment before the final microbiological results are available. This causes distribution and susceptibility of UTlI-causing pathogens to change according to time and place.’ Studies from the Nepal, India and other areas of Bangladesh have reported an increased resistance of the urinary pathogens to commonly-used antibiotics”!. But there has not been any report about antimicrobial resistance pattern in Bogra. So, in his present setting, the frequency of UTI and anti-microbial resistance pattern in the treatment of UTI as well as what should now be the choice of antibiotics in the treatment of UTI were investigated.