TMSS Medical College Journal

Background: Thyroid hormones play an important role in human metabolism. Erythrocytes abnormalities are frequently associated with thyroid disorder. Disorders of these hormones cause an effect on hematological indices levels. AIM- evaluate the effect of thyroid disorders on different hematological indices levels. Materials and Methods : This study was conducted Blood sample from 70 thyroid disorders patients (40 hypothyroid and 30 hyperthyroid) and 80 control subjects were evaluated. Haematological parameters like Hemoglobin, MCV (mean corpuscular volume), MCHC (mean corpuscular hemoglobin concentration) WBC and platelet parameter were evaluated and other routine haemogram were studied. Biochemical parameter like T3, T4 and TSH were measured. A comparison was done on different parameters Results : A statistical difference was observed for MCV and MCH but other parameters did not show any statistically significant difference. Conclusion : All the patients with thyroid disorders should be periodically evaluated for hematological changes.

The thyroid gland is the largest endocrine gland of human body. It synthesizes and secretes two major hormones-3, 5, 3 triiodo thyronine (T3) and thyroxin (T4). These hormones are necessary for metabolic activity of the body. These also have important role in early brain development, somatic growth, bone maturation, protein synthesis and production of red blood cells. These hormones are under the control of TSH (thyroid stimulating hormone) secreted by anterior pituitary which itself is mediated by TRH (thyrotropin-releasing ~~ hormone) secreted by hypothalamus. Thyroid hormones also play an important role in hemoglobin production in adult and maturation of Hb in fetus." Thyroid hormones has effect on erythropoiesis. They cause hyper proliferation of immature erythroid progenitors and induce erythropoietin gene expression thus increasing secretion of erythropoietin leading to increased erythropoiesis. Thyroid disorders are accompanied by red blood cell abnormalities. Thyroid disorders can induce different effects on various blood cell lineages. Hypothyroidism can cause various forms of anemia (normocytic-normochromic, microcytic, hypochromic or macrocytic). Patients with hypothyroidism have a decreased erythrocyte mass due to reduction of plasma volume whereas increased erythrocyte mass is observed in most hyperthyroid patients. Alteration in other hematological parameters such as hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), white blood cells (WBC) count and platelet count is | associated with thyroid dysfunction.’ In the present study, we attempted to evaluate the effect of thyroid | dysfunction on various hematological parameters. |