TMSS Medical College Journal

Background: The distribution of urinary pathogens and their resistance pattern to antimicrobial drugs vary regionally and even in the same region. Objective: The purpose of this study was to determine the prevalence of bacteriological pattern that causes UTIs and to assess their sensitivity to commonly used antimicrobial agents in Rangpur community medical college hospital. Methodology: This cross sectional study was conducted by gaining the required information from the patient’s records to find out the causative pathogens & their antibiotic sensitivity patter in of urinary tract infections (UTIs) patients. Midstream urine samples were processed for microscopy and culture; the organisms were identified by standard methods. Antimicrobial sensitivity was carried out by Kirby- Bauer disk diffusion method according to clinical and laboratory standards institute guidelines. Result: Out of total 542 mid- stream urine samples collected from suspected cases of UTIs of which total 273 (50.06%) samples were positive for urine culture. Of 273 culture positive samples of which 97 (35.53%) were males and 176 (64.46%) were females indicating that prevalence of UTIs is higher in females than males. Maximum patients were from 21-30 yrs age group. Escherichia coli (56.04%) was found the most common organism followed by Staphylococcus species (36.26%), Klebsiella species (1.09%) and Pseudomonas species (0.73%). Escherichia coli was more sensitive to meropenem (98.68%), nitrofurantoin (95.65%), amikacin (92.15%) and least sensitive to most commonly used drugs like cefuroxime (35.92%), cefixime ( 43.39%) , cotrimoxazole (47.71%) and ciprofloxacin ( 48.92%). Conclusion: Escherichia coli is still the most common uropathogen & the choice of drugs in the treatment of UTIs is quite narrow today due to wide range of resistance of commonly used drugs which have been used previously.

Urinary tract infections (UTIs) are the second most common infections observed in clinical practice after the infections of the respiratory tract.! It was reported that approximately 10% of humans are being affected by UTIs at some stage during their lifetime.” The appropriate treatment of UTIs constitutes a great proportion of prescription of antibiotic and the choice of antibiotics is affected by local resistance pattern of uropathogens.’ The distribution of urinary pathogens and their resistance pattern to antibiotics vary regionally therefore it is important to have regional hospital based knowledge of causative urinary pathogens and their susceptibility pattern to various antibiotics.* Periodic evaluation of antimicrobial susceptibility is essential as the pattern of antibiotic sensitivity may vary over short periods of time. Treatment of UTIs constitutes a major portion of prescription of antibiotics and urinary pathogens have shown a changing pattern of susceptibility to antibiotics, thus there is an increase in resistance pattern to commonly prescribed antibiotics. The antibiotic resistance is a global problem and requires taking measures to combat this problem. The distribution of urinary pathogens and their resistance pattern to antimicrobial drugs vary regionally and even in the same region. Therefore it is necessary to identify the causative pathogens and their susceptibility to various antibiotics for a better therapeutic outcome. The purpose of this study is to determine the prevalence of bacteriological pattern that causes urinary tract infections and to assess their sensitivity to commonly used antimicrobial agents in Rangpur community medical college hospital.