Primary Hepatic Neuroendocrine Carcinoma: A Case Presentation
Abstract
Primary hepatic neuroendocrine carcinomas (PHNECS) are exceedingly rare and unlike metastatic neuroendocrine
tumor rarely cause carcinoid syndrome. We present a case of a 54 -year-old male with a primary hepatic
neuroendocrine carcinoma which presented as abdominal discomfort and fatigue. The case presented required
meticulous radiological, histopathological, and serological work-up to rule out an occult extrahepatic malignancy with
hepatic metastasis to confirm the primary nature of hepatic tumors.
Keywords
Neuroendocrine tumor
immunohistochemistry
liver.
Introduction
Neuroendocrine tumors develop in organs or tissues that contain peptide- and amine-producing cells with different hormonal profiles depending on their site of origin.! OF all neuroendocrine tumors, approximately 57.0% and 27.0% arise within the gastroenteropancreatic system and bronchopulmonary system, respectively.2 Within the gastrointestinal tract, most neuroendocrine tumors occur in the rectum (17.2%), jejunumyileum (13.4%), and pancreas (6.4%).[2] Primary hepatic neuroendocrine carcinomas (PHNECs) are extremely rare. We present the case of a man with Primary hepatic neuroendocrine carcinoma,