TMSS Medical College Journal

Polycystic ovary syndrome (PCOS) is a common condition characterized by menstrual abnormalities and clinical or biochemical features of hyperandrogenism and may manifest at any age. The present study was carried out at different hospitals and privet chambers (northan region of Bangladesh), from January 2012 to December 2014, on 50 women with PCOS which was diagnosed by three criteria: (1) oligovulation and/or anovulation, (2) hyperandrogenism and (3) polycystic ovaries. Most common age was 21-25 years (44%), mean BMI 27.10 kg/m?, menstrual cycle irregularity 80%, oligomenorrhoca 28%, dysmenorrhoea 18%, nulliparity 90%, history of abortion 10%, acne in 52%, hirsutism in 50%, and per vaginal findings were anteverted uterus 100%, free fornices 98% and healthy cervix 94%. Laboratory findings were low serum FSH 2% (2.8 mIU/ml), raised serum LH 56% (>14.7 mIU/ml). LH: FSH retio increased more than 3:1, raised blood sugar (2hr after 75 g glucose load) 30% (7.8 mmol/L), raised serum prolactin 14% (>25 ng/ml), raised serum TSH 2% (>4 IU/ml), low T, (<3.5 ng/dl), ultrasound of lower abdomen showed evidence of PCOS in 100% cases. Infertility in women with PCOS can be treated successfully in most women by dict and exercise, clomiphene citrate with or without metformin, laparoscopic ovarian diarthermy, or ovulation induction with gonadotrophins.

The polycystic ovary syndrome (PCOS), one of the most common causes of infertility due to anovulation, affects 47% of women!. The PCOS syndrome is a heterogenous condition which is defined by the presence of two out of the following three criteria (Rottardum criteria): (1) oligo and/or anovulation, (2) hyperandrogenism (clinical and/or biochemical) and (3) polycistic ovaries, with the exclusion of other aetiologies’. According to study, basic diagnostic criteria should be the presence of hyperandrogenism and chronic oligoanovulation, with the exclusion of other causes of hyperandrogenism such as adult onset congenital adrenal hyperplasia, hyperprolactinaemia and ~~ androgensecreting neoplasms”. A consensus conference held in Rotterdam agreed on the appropriateness of including ultrasound morphology of the ovaries as a further potential criteria to define the PCOS but also established that at least two of the following criteria are sufficient for the diagnosis: oligo and/or anovulation, clinical and/or biochemical signs of hyperandrogenism and polycystic ovaries at ultrasound®. The pathophysiology of PCOS may have a genetic component although it can be suggested that the main factors responsible for the increasing prevalence of PCOS are related to the influence of the environment, including dietary habits, behaviour and other still undefined factors’. The clinical features of PCOS are heterogeneous and may change throughout the lifespan, starting from adolescence to postmenopausal age’. This is largely dependent on the influence of obesity and metabolic syndrome, which consistently affect most women with PCOS’. This represents an important factor in the evaluation of the PCOS throughout life and relevant to young and fertile women but may also have some health implications later in life.