TMSS Medical College Journal

Background: Bacteria belonging to the genus Klebsiella frequently causes human nosocomial infections, poses a new problem to health care professionals worldwide, which complicates and limits therapeutic options. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-biotic policies. Objective: This study was undertaken to see frequency of Klebsiella spp among Hospital and Community acquired infection and their sensitivity pattern. Methodology: This cross sectional study was carried out in the department of Microbiology at Mymensingh Medical College from January 2011 to June 2011 for a period of 6 months. Specimens were processed and bacteria were isolated and identified according to standard procedure. Antibiogram profile of these isolates was determined by Kirby-Bauer's disc diffusion method on Muller Hinton agar media. Result: A total of 300 gram negative isolates were taken. Among them urine were 216 (72%), wound swab 45 (15%), pus 39 (13%). Of the 45(15%) Klebsiella spp. hospital and community acquired isolates were 17 (37.77%) and 28 (62.225%) respectively. All the isolates were sensitive to imipenem and nitrofurantoin followed by amikacin 70%. A relatively higher rate of resistance to gentamicin, co-trimoxazole, azithromycin and quinolones were also observed. Conclusion: This study helps to suggested that Klebsiella spp were not only common in Hospital acquired infection but also in community this study reveals that Klebsiella spp isolated were multidrug resistant in this area.

Klebsiella spp, a common intestinal microflora has been associated with diverse disease syndromes ranging from Urinary tract infection (UTI), pneumonia, blood stream infections, wound or surgical site infections and meningitis. Klebsiella spp. is a Gram-negative, non- motile, encapsulated, lactose fermenting, facultative anaerobic, rod shaped bacterium, citrate positive, some are Indole positive found in the normal flora of the mouth, skin, and intestines that can cause different types of health care infection? Klebsiella was named after the German bacteriologist Edwin Klebs (1834-1913) in 1884. It naturally occurs in the soil. Klebsiella spp. is an opportunistic pathogen frequently implicated in respiratory and urinary tract infections of hospitalized patients,particularly in chronic alcoholics and diabetis mellitus