TMSS Medical College Journal

Background: Histopathological examination of colonic mucosal biopsies is crucial for the identification of a number of conditions, including inflammatory and infectious disorders, as well as benign and malignant neoplasms. Examining the histomorphological range of colonic samples taken from two important diagnostic centers in Gazipur, Bangladesh, is the aim of this study. Materials and Methods: A retrospective analysis of 350 colonoscopic biopsy specimens obtained from Tairunnessa Memorial Medical College and Popular Diagnostic Center, Gazipur Branch, over a three-year period (January 2022-March 2025) was carried out. Hematoxylin and eosin staining and standard processing were applied to the specimens. Age, sex, lesion distribution, and histological findings were examined in these instances. Results: Out of the 350 cases, 259 were male and the rest were female. The cases ranged in age from 20 to 78. The rectosigmoid area was the site of the majority of the biopsies. Adenomatous polyps, tubulovillous adenomas with dysplasia, and adenocarcinomas were among the neoplastic lesions, but nonspecific colitis and ulcerative colitis accounted for the majority of the observations. There were also a few isolated incidences of Crohn's disease and TB. Conclusion: Variety of gastrointestinal illnesses can be diagnosed with the help of colonic biopsies. Managing patients requires accurate histomorphological assessment, particularly when separating benign, infectious, and malignant disorders.

Colorectal diseases are expensive for healthcare systems worldwide because they cause both acute and chronic morbidity.” Due to dietary changes, urbanization, and better access to healthcare, more colonoscopic procedures are being performed in Bangladesh and other developing countries.’ Samples of the colon obtained during these operations are crucial for the diagnosis of a variety of discascs, ranging from nonspecific inflammation to malignancy.” For assessing colonic lesions, histopathological investigation is still the gold standard, especially when endoscopic findings and clinical symptoms coincide.’ Clinically and endoscopically, conditions including Crohn's disease, ulcerative colitis, and. infectious | colitis frequently exhibit identical symptoms.* Similarly, the carly stages of cancer might resemble benign illnesses, therefore histological confirmation is essential.®