TMSS Medical College Journal

Background: In Bangladesh, the prevalence (34%) of Type 2 Diabetes Mellitus patients with chronic kidney disease is rising in recent years. There is lack of studies on the prescribing patterns of antidiabetic drugs in our country regarding Type 2 Diabetes Mellitus with chronic kidney disease patients. Objective: The aim of this study was to assess the prescribing pattern of antidiabetic drugs in Type 2 Diabetes Mellitus with chronic kidney disease patients. Materials and Methods: A cross sectional study was performed from July 2022 to June 2023, by analyzing patients attending OPD of Endocrinology and Nephrology Department of SSMCMH. Total 344 participants were enrolled after meeting the selection criteria. Results: Mean age of the participants was 63.6 years with a male gender predominance (58.2%). Mean HbA lc was 7.5. Majority of the participants (39.5%) were in stage 3b kidney discase. DPP-4 inhibitors were frequently prescribed as single drug (23.5%) and also SGLT2 inhibitors (16.0%). Among the combination therapy, insulin + DPP-4 inhibitor (28.8%) was used mostly prescribed followed by metformin + SGLT? inhibitor (12.5%). Conclusion: In our study the combination of metformin and SGLT 2 inhibitor were found to be used frequently when GFR is >30ml/min. Nonetheless, it is evident that its utilization was lesser in the previous year than it is currently. Thus, we can conclude that this medications have been used more frequently in recent years. This finding may further help to conduct a comparative study to assess the kidney function between those who are received this combination group and those who are not.

Diabetes Mellitus has become one of the most common non communicable diseases and also become one of the fastest growing global health emergencies of the 21st century. About 536.6 million people found to be suffering from Diabetes Mellitus globally. In Bangladesh there is a dreadful rise in this discase’s progression from 8.4 million in 2011 to 13.1 million by 2021. It is alarming that, Bangladesh is in the top 8" position among other countries of the world regarding this." It is fundamental for people with Diabetes Mellitus to be diagnosed as early as possible to prevent or delay complications, avoid a premature death, decrease healthcare cost and improve quality of life. People with uncontrolled Diabetes Mellitus has an increased risk of developing life threatening micro and macro vascular complications.? Uncontrolled Diabetes Mellitus can be prevented by using appropriate antidiabetic agents.” * A previous study showed that 1% reduction of mean HbA c significantly reduces diabetes related deaths (21%) as well as microvascular complications (37%).