TMSS Medical College Journal

Introduction: COVID-19 pandemic is affecting Bangladesh like other countries and its early detection, management became major public health concern of the government as well as private sector. So, this present study was conducted to systematically analyze RT-PCR, HRCT of chest in COVID-19 subjects and to detect diagnostic accuracy of HRCT of chest comparing RT-PCR as gold standard. Materials and Methods: This observational study was carried out enrolling 266 study subjects at Department of Medicine in TMSS Medical College and Rafatullah Community Hospital, Bogura. Suspected subjects of novel coronavirus infection who underwent both chest CT imaging and laboratory virus nucleic acid test (RT-PCR assay with throat swab samples) were included in this study. Demographic characteristics, co-morbidities and symptoms were recorded. Results: Sensitivity, Specificity, PPV, NPV of RT PCR for detection of COVID-19 infection was 89.4%, 76.6%, 95% and 7% respectively. Considering RT-PCT as gold standard test, Sensitivity, Specificity, PPV, NPV of HRCT chest for Detection of presence of COVID -19 infection were 94.8%, 85.7%, 99.1% and 48% respectively. Conclusion: HRCT of chest was a comparable tool for detection of presence of COVID -19 infection.

Since December 2019, a number of cases of “unknown viral pneumonia” related to a local Seafood Wholesale Market were reported in Wuhan City, Hubei Province, China." A novel coronavirus (SARS-CoV-2) was suspected to be the etiology with Phinolophus bat as the alleged origin. The coronavirus pandemic has infected more than 9.6 million people and killed more than 16,665,702 worldwide since late January, when it was first reported.’ The outbreak spread from the Chinese city of Wuhan to more than 180 countries and territories—affecting every continent except Antarctica.’ In absence of specific therapeutic drugs or vaccines for 2019 novel coronavirus disease (COVID-19), it is essential to detect the diseases at an early stage, and immediately isolate the infected person from the healthy population.